Caliberi® Tadalafil Orodispersible Films 20mg (4 films)

What is Caliberi® used for​​​?

Caliberi® contains the active ingredient, Tadalafil. Tadalafil is used to treat erectile dysfunction, a condition where you are unable to get or keep an erection firm enough to have sexual intercourse. It works by relaxing the blood vessels in your penis, allowing blood to flow into your penis when you get sexually excited. This medicine will only help you to get an erection if you are sexually stimulated.

Dosage and how to use

For the treatment of erectile dysfunction

• Caliberi® must be immediately used once taken out of the pouch and it can be dissolved on the tongue, with or without any water.
• Caliberi® should be taken without food
• Do not take more than once a day. However, if you find yourself taking Caliberi® 20mg everyday continuously, speak to your doctor about switching to a lower dose, daily regimen of Caliberi® 5mg instead.
• Do not take more than the dose prescribed to you.
• It usually starts to work within 30 minutes and is effective up to 36 hours before sexual activity. 

When do I take Caliberi® 5mg vs Caliberi® 20mg?

• How often do you have sex? If it's two or more times a week, a daily pill might be a reasonable choice, since the drug continually circulates in your bloodstream.
• How important is spontaneity? A daily pill clears the path for sex at any time, any day. On the other hand, the 36-hour window offered by the non-daily version of Cialis might offer enough spontaneity.
• Have side effects of your current ED pill been bothering you? Taking a daily low-dose pill may reduce side effects, though it may reduce effectiveness as well.

How effective is Tadalafil for Erectile Dysfunction?

Tadalafil has been shown to be highly effective in ED treatment. 3 studies with a total of over 1000 patients demonstrated significant improvement in erectile function and the ability to have successful sexual intercourse up to 36 hours following Tadalafil dosing.

The effects of Tadalafil last noticeably longer than that of Sildenafil (Viagra), normally up to 36 hours. This, however, does not mean you will have an erection for a day and a half. Instead, you will be able to achieve an erection within that 36-hour period.

What are the possible side effects of Caliberi®?​

• Facial flushing where the skin on your face feels hot
• Headache
• Nausea 
• Back pain, muscle aches, pain in arms and legs
• Nasal congestion 
• Very rarely, priapism (an erection that will not go away) - If you have an erection that lasts more than 4 hours, get medical help right away. If it is not treated right away, priapism can permanently damage your penis.

What precautions should I take?

Inform your healthcare professional if: 

• You are allergic to this medication or any of the other ingredients of this medication
• You are taking medicines called Nitrates (such as sublingual nitroglycerin (also known as Glycerin Trinitrate or GTN), Isosorbide Mononitrate or Isosorbide Dinitrate), as the combination may lead to a dangerous fall in your blood pressure. Nitrates must be withheld at least 24 hours after the last dose of Sildenafil or Vardenafil, and 48 hours after the last dose of Tadalafil. 
• Tell your doctor if you are taking any of these medicines which are often given for relief of angina (chest pain).  If you are not certain, ask your healthcare professional. 
• You are taking medicines called Alpha-1 Blockers (such as Tamsulosin, Terazosin, Prazosin, Alfuzosin), as the combination may further lower your blood pressure. In order to reduce the chances of these symptoms occurring, you should be on a regular daily dose of your Alpha-blocker before you start drugs for erectile dysfunction.
• You recently had a stroke or a heart attack, low blood pressure or uncontrolled high blood pressure 
• You have severe heart, liver or kidney  problem 
• You have certain rare inherited eye diseases (such as retinitis pigmentosa)
• You have a stomach ulcer or bleeding problem
• You have a deformity of your penis 

What other medications and foods should I avoid when taking Caliberi®?

Avoid taking grapefruit, or grapefruit juice as they may interact with your medication and increase the risk of side-effects.

Drinking alcohol can temporarily weaken your ability to get an erection and may increase the blood pressure lowering effects of the medication, which can be dangerous. To get the maximum benefit from your medication, it is advisable not to drink excessive amounts of alcohol before taking this medication. 

Inform your healthcare professional if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies.

This includes certain medications such as:

• Antibiotics
• Anti-fungal medications
• Medications used to treat human immunodeficiency virus (HIV) infection
• Medications for epilepsy (fits)

Handling and storage

• Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. 
• Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

References

https://www.healthhub.sg/a-z/medications/340/Tadalafil

https://www.mims.com/singapore/drug/info/caliberi